Improving Treatment of Diseases with Rapid Therapeutic Discovery

Advances in synthetic and molecular biology have accelerated the discovery and optimization of therapeutic proteins, known as Biologics.

DD-LP-workflow

Streamlined Antibody Development

Biologics are an important class of drugs for the treatment of a wide spectrum of disorders, including autoimmune, metabolic, neurologic, infectious diseases, cancer, and more. Twist Biopharma, a division of Twist Bioscience, leverages our team of experts and precise library technology to build focused phage display libraries for biologic drug discovery.

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Innovative Technology

Innovative Technology

High throughput DNA synthesis underpins the rapid expansion of discovery and optimization efforts in the biologics discovery space. Twist Bioscience’s unique DNA writing technology enables the synthesis of millions of DNA oligonucleotides simultaneously with unparalleled diversity and precision coupled with game-changing throughput and quality.

Libraries for Antibody Development


In-house, these same oligo pools underpin our Synthetic Protein Library technology. Researchers use our Site-Saturation Variant Libraries and Combinatorial Variant Libraries for the discovery and optimization of new biologic candidates.
 

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Oligo Pools for Target Identification


Industrial researchers utilize our oligo pools to power high throughput functional genomics screens for target identification and validation. 




 

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Partnerships for Full Biologics Programs


Twist Biopharma uses our library technology to build focused phage display libraries. Through multiple rounds of binding selection, we enrich for high-affinity clones which provides the basis for our antibody discovery optimization services. 
 


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High Throughput Functional Screens to Identifty Druggable Targets

High Throughput Functional Screens to Identifty Druggable Targets

While Twist’s oligo pools form the foundation for synthetic library synthesis, scientists also use them to undertake high throughput screens that drive the identification of new druggable targets, including high throughput peptide discovery screens, and high throughput functional genomic screens like CRISPR and FISH. Hear from Dr. Benedict Cross from PhoreMost about how they discover new druggable targets using Twist’s long oligos in their SITESEEKER platform.

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Enhancing the Therapeutic Properties of a Cancer-Targeting Affibody

Enhancing the Therapeutic Properties of a Cancer-Targeting Affibody

See how researchers at the at the KTH Royal Institute of Technology and Uppsala University are using Twist’s Combinatorial Variant Libraries to engineer previously identified affibody molecules targeting VEGFR2 for basic biological research into the vascularization process and potentially target the treatment of several diseases including cancer and macular degeneration.

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Comprehensive Drug Discovery Guide

Comprehensive Drug Discovery Guide

Still in need of more information on what exactly that journey looks like going from a target to a molecule? Twist Biopharma is here to support you through the journey.

This process is long, with most companies taking approximately 12 years to move from the first patent filing to FDA approval. The multi-year journey may feel overwhelming, but it can be broken up into short-term goals and milestones as you will see in this comprehensive Antibody Discovery and Development Guide.

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Here's what our customers are saying
Twist 是唯一能够以我们项目所需的数量和质量交付 DNA 的合成 DNA 提供商。We are working with them not only as a vendor for synthetic genes and antibodies, but have expanded our relationship to leverage the Biopharma capabilities, which we believe complement our antibody discovery efforts.
Robert Carnahan, Ph.D.
Vanderbilt 疫苗中心的副主任

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