我们的 DNA 中存在多样性
像您一样的人们正在创造未来。在 Twist，因为 Twist 人每天都在给他们的工作加入各种各样的经历和背景，这使得我们都变得更加强大。以下是 Twist 在全球的一些驻点，Twist 员工在这些地方不断成长。
领导团队
-
Emily Leproust 博士
Twist 首席执行官兼联合创始人
查看个人简历/出版物x
Emily Leproust 博士
Twist 首席执行官兼联合创始人
作为高通量合成和 DNA 测序的先驱者，Leproust 博士正在颠覆市场，以实现 DNA 应用的指数级增长，包括化学品/材料、诊断、治疗、食品和数字数据存储。2020 年，BIO 向她颁发了 Rosalind Franklin 领导奖。《外交政策》杂志将她评为 100 位全球领先思想家之一，而 Fast Company 则将她评为商界最具创造力的人物之一。加入 Twist Bioscience 之前，她曾在 Agilent Technologies 履任要职，期间曾设计出大获成功的 SureSelect 生产线，从而降低了测序成本，并阐明了数十种孟德尔疾病的机制。她还开发了寡核苷酸库合成技术，并启动和领导了团队的产品和业务拓展活动。Leproust 博士设计并开发了多个商业合成平台，用于简化微阵列芯片的生产制造过程。She serves on the Board of Directors of GeneDx and is a co-founder of Petri, an accelerator for start-ups at the forefront of engineering and biology. Leproust 博士发表过 30 多篇经过同行评议的论文，其中许多是关于合成 DNA 的应用，同时她还是多项专利的作者。她曾在休斯顿大学取得有机化学博士学位，并在里昂工业化学学院取得工业化学硕士学位。
出版物
Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsinsBedbrook CN, Rice AJ, Yang KK, Ding X, Chen S, LeProust EM, Gradinaru V, Arnold FH.
PNAS. 2017 114(13) E2624-E2633Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genomeSchoenfelder S, Sugar R, Dimond A, Javierre B, Armstrong H, Mifsud B, Dimitrova E, Matheson L, Tavares-Cadete F, Furlan-Magaril M, Segonds-Pichon A, Jurkowski W, Wingett SW, Tabbada K, Andrews S, Herman B, LeProust EM, Osborne CS, Koseki H, Fraser P, Luscombe NM, Elderkin S.
Nature Genetics. 2015 47 1179–1186Mapping long-range promoter contacts in human cells with high-resolution capture Hi-CMifsud B, Tavares-Cadete F, Young AN, Sugar R, Schoenfelder S, Ferreira L, Wingett SW, Andrews S, Grey W, Ewels PA, Herman B, Happe S, Higgs A, LeProust EM, Follows GA, Fraser P, Luscombe NM, Osborne CS.
Nature Genetics. 47 (6) 598-606.The pluripotent regulatory circuitry connecting promoters to their long-range interacting elementsSchoenfelder S, Furlan-Magaril M, Mifsud B, Tavares-Cadete F, Sugar, R, Javierre B, Nagano T, Katsman Y, Sakthidevi M, Wingett SW, Dimitrova E, Dimond A, Edelman LB, Elderkin S, Tabbada K, Darbo E, Andrews S, Herman B, Higgs A, LeProust EM, Osborne CS, Mitchell JA, Luscombe NM, Fraser P.
Genome Res. 2015. 25: 582-597Utilizing ethnic-specific differences in minor allele frequency to recategorize reported pathogenic deafness variantsShearer AE, Eppsteiner RW, Booth KT, Ephraim SS, Gurrola J, Simpson A, Black-Ziegelbein EA, Joshi S, Ravi H, Giuffre AC, Happe S, Hildebrand MS, Azaiez H, Bayazit YA, Erdal ME, Lopez-Escamez JA, Gazquez I, Tamayo ML, Gelvez NY, Leal GL, Jalas C, Ekstein J, Yang T, Usami S, Kahrizi K, Bazazzadegan N, Najmabadi H, Scheetz TE, Braun TA, Casavant TL, LeProust EM, Smith RJ.
The American Journal of Human Genetics. 95 4 445-453
Systematic Identification of Barriers to Human iPSC Generation
Qin H, Diaz A, Blouin L, Lebbink RJ, Patena W, Tanbun P, LeProust EM, McManus MT, Song JS, Ramalho-Santos M.
158 (2) 449–461
A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation
van de Weijer ML, Bassik MC, Luteijn RD, Voorburg CM, Lohuis MA, Kremmer E, Hoeben RC, LeProust EM, Chen S, Hoelen H, Ressing ME, Patena W, Weissman JS, McManus MTa, Wiertz, EJa, and Lebbink RJa.
Nat Commun. (2014) 5: 3832.Evidence for the biogenesis of more than 1,000 novel human microRNAsFriedländer MR, Lizano E, Houben AJS, Bezdan D, Báñez-Coronel M, Kudla G, Mateu-Huertas E, Kagerbauer B, González J, Chen KC, LeProust EM, Martí E, Estivill X.
Genome biology. 2014 15:R57Exonic Transcription Factor Binding Directs Codon Choice and Affects Protein EvolutionStergachis AB, Haugen E, Shafer A, Fu W, Vernot B, Reynolds A, Raubitschek A, Ziegler S, LeProust EM, Akey JM, Stamatoyannopoulos JA.
Science. 2013 342(6164) 1367-1372Advancing genetic testing for deafness with genomic technology.Shearer AE, Black-Ziegelbein EA, Hildebrand MS, Eppsteiner RW, Ravi H, Joshi S, Guiffre AC, Sloan CM, Happe S, Howard SD, Novak B, Deluca AP, Taylor KR, Scheetz TE, Braun TA, Casavant TL, Kimberling WJ, Leproust EM, Smith RJ.
Journal of Medical Genetics. 2013 50(9) 627-34A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility.Bassik MC, Kampmann M, Lebbink RJ, Wang S, Hein MY, Poser I, Weibezahn J, Horlbeck MA, Chen S, Mann M, Hyman AA, Leproust EM, McManus MT, Weissman JS.
Cell. 2013 152(4) 909-22Towards practical, high-capacity, low-maintenance information storage in synthesized DNA.Goldman N, Bertone P, Chen S, Dessimoz C, LeProust EM, Sipos B, Birney E.
Nature. 2013 494(7435) 77-80Targeted genome enrichment for efficient purification of endosymbiont DNA from host DNA.Geniez S, Foster JM, Kumar S, Moumen B, Leproust E, Hardy O, Guadalupe M, Thomas SJ, Boone B, Hendrickson C, Bouchon D, Grève P, Slatko BE.
Symbiosis. 2012 58 (1-3) 201-207Mitochondrial disease genetic diagnostics: optimized whole-exome analysis for all MitoCarta nuclear genes and the mitochondrial genome.Falk MJ, Pierce EA, Consugar M, Xie MH, Guadalupe M, Hardy O, Rappaport EF, Wallace DC,LeProust E, Gai X.
Discovery Medicine. 2012 14(79) 389-99Pre-capture multiplexing improves efficiency and cost-effectiveness of targeted genomic enrichment.Shearer AE, Hildebrand MS, Ravi H, Joshi S, Guiffre AC, Novak B, Happe S, LeProust EM, Smith RJ. BMC Genomics. 2012 13 618Target enrichment strategies for next generation sequencing.Leproust E.
Medical Laboratory Observer. 2012 44(6) 26-7Myofibrillar myopathy caused by a mutation in the motor domain of mouse MyHC IIb.Kurapati R, McKenna C, Lindqvist J, Williams D, Simon M, LeProust E, Baker J, Cheeseman M, Carroll N, Denny P, Laval S, Lochmüller H, Ochala J, Blanco G.
Human Molecular Genetics. 2012 21(8) 1706-24Specific capture and whole-genome sequencing of viruses from clinical samples.Depledge DP, Palser AL, Watson SJ, Lai IY, Gray ER, Grant P, Kanda RK, Leproust E, Kellam P, Breuer J.
PLoS One. 2011 6(11) e27805Autoantigen discovery with a synthetic human peptidome.Larman HB, Zhao Z, Laserson U, Li MZ, Ciccia A, Gakidis MA, Church GM, Kesari S, Leproust EM, Solimini NL, Elledge SJ.
Nature Biotechnology. 2011 29(6) 535-41Efficient and cost effective population resequencing by pooling and in-solution hybridization.Bansal V, Tewhey R, Leproust EM, Schork NJ.
PLoS One. 2011 6(3) e18353The GENCODE exome: sequencing the complete human exome.Coffey AJ, Kokocinski F, Calafato MS, Scott CE, Palta P, Drury E, Joyce CJ, Leproust EM, Harrow J, Hunt S, Lehesjoki AE, Turner DJ, Hubbard TJ, Palotie A.
European Journal Human Genetics. 2011 19(7) 827-31Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips.Kosuri S, Eroshenko N, Leproust EM, Super M, Way J, Li JB, Church GM.
Nature Biotechnology. 2010 28(12) 1295-9Temporal and spatial profile of brain diffusion-weighted MRI after cardiac arrest.Mlynash M, Campbell DM, Leproust EM, Fischbein NJ, Bammer R, Eyngorn I, Hsia AW, Moseley M, Wijman CA.
Stroke. 2010 41(8) 1665-72Synthesis of high-quality libraries of long (150mer) oligonucleotides by a novel depurination controlled process.LeProust EM, Peck BJ, Spirin K, McCuen HB, Moore B, Namsaraev E, Caruthers MH.
Nucleic Acids Research. 2010 38(8) 2522-40Enrichment of sequencing targets from the human genome by solution hybridization.Tewhey R, Nakano M, Wang X, Pabón-Peña C, Novak B, Giuffre A, Lin E, Happe S, Roberts DN,LeProust EM, Topol EJ, Harismendy O, Frazer KA.
Genome Biology. 2009 10(10) R116Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human.Zhang K, Li JB, Gao Y, Egli D, Xie B, Deng J, Li Z, Lee JH, Aach J, Leproust EM, Eggan K, Church GM.
Nature Methods. 2009 6(8) 613-8Multiplex padlock targeted sequencing reveals human hypermutable CpG variations.Li JB, Gao Y, Aach J, Zhang K, Kryukov GV, Xie B, Ahlford A, Yoon JK, Rosenbaum AM, Zaranek AW, LeProust E, Sunyaev SR, Church GM.
Genome Research. 2009 19(9) 1606-15Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing.Li JB, Levanon EY, Yoon JK, Aach J, Xie B, Leproust E, Zhang K, Gao Y, Church GM.
Science. 2009 324(5931) 1210-3Rapid creation and quantitative monitoring of high coverage shRNA libraries.Bassik MC, Lebbink RJ, Churchman LS, Ingolia NT, Patena W, LeProust EM, Schuldiner M, Weissman JS, McManus MT.
Nature Methods. 2009 6(6) 443-5Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming.Deng J, Shoemaker R, Xie B, Gore A, LeProust EM, Antosiewicz-Bourget J, Egli D, Maherali N, Park IH, Yu J, Daley GQ, Eggan K, Hochedlinger K, Thomson J, Wang W, Gao Y, Zhang K.
Nature Biotechnology. 2009 27(4) 353-60Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells.Ball MP, Li JB, Gao Y, Lee JH, LeProust EM, Park IH, Xie B, Daley GQ, Church GM.
Nature Biotechnology. 2009 27(4) 361-8Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing.Gnirke A, Melnikov A, Maguire J, Rogov P, LeProust EM, Brockman W, Fennell T, Giannoukos G, Fisher S, Russ C, Gabriel S, Jaffe DB, Lander ES, Nusbaum C.
Nature Biotechnology. 2009 27(2) 182-9The DNA-encoded nucleosome organization of a eukaryotic genome.Kaplan N, Moore IK, Fondufe-Mittendorf Y, Gossett AJ, Tillo D, Field Y, LeProust EM, Hughes TR, Lieb JD, Widom J, Segal E.
Nature. 2009 458(7236) 362-6Multiplex amplification of large sets of human exons.Porreca GJ, Zhang K, Li JB, Xie B, Austin D, Vassallo SL, LeProust EM, Peck BJ, Emig CJ, Dahl F, Gao Y, Church GM, Shendure J.
Nature Methods. 2007 4(11) 931-6Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis.Cleary MA, Kilian K, Wang Y, Bradshaw J, Cavet G, Ge W, Kulkarni A, Paddison PJ, Chang K, Sheth N, Leproust E, Coffey EM, Burchard J, McCombie WR, Linsley P, Hannon GJ.
Nature Methods. 2004 1(3) 241-8Effects of atmospheric ozone on microarray data quality.Fare TL, Coffey EM, Dai H, He YD, Kessler DA, Kilian KA, Koch JE, LeProust E, Marton MJ, Meyer MR, Stoughton RB, Tokiwa GY, Wang Y.
Analytical Chemistry. 2003 75(17) 4672-5A flexible light-directed DNA chip synthesis gated by deprotection using solution photogenerated acids.Gao X, LeProust E, Zhang H, Srivannavit O, Gulari E, Yu P, Nishiguchi C, Xiang Q, Zhou X.
Nucleic Acids Research. 2001 29(22) 4744-50.Characterization of oligodeoxyribonucleotide synthesis on glass plates.LeProust E, Zhang H, Yu P, Zhou X, Gao X.
Nucleic Acids Research. 2001 29(10) 2171-80Unexpected formation of parallel duplex in GAA and TTC trinucleotide repeats of Friedreich's ataxia.LeProust EM, Pearson CE, Sinden RR, Gao X.
Journal of Molecular Biology. 2000 302(5) 1063-80Digital light-directed synthesis. A microarray platform that permits rapid reaction optimization on a combinatorial basis.LeProust E, Pellois JP, Yu P, Zhang H, Gao X, Srivannavit O, Gulari E, Zhou X.
Journal of Combinatorial Chemistry. 2000 2(4) 349-54An efficient and economic site-specific deuteration strategy for NMR studies of homologous oligonucleotide repeat sequences.Huang X, Yu P, LeProust E, Gao X.
Nucleic Acids Research. 1997 25(23) 4758-63 -
Patrick Finn
President and Chief Operating Officer
查看个人简历/出版物x
Patrick Finn
President and Chief Operating Officer
Patrick 此前在生物试剂、B2B 和定制制造企业有着良好表现，成功实现了销售额的高速增长。他拥有相关的技术背景，并且能够识别出客户未被满足的需求，因此适合领导我们的商务工作。Paddy 在加入 Twist Bioscience 之前任职于 Enzymatics（近期被 QIAGEN 收购），担任销售与市场副总裁，负责领导北美和欧洲的商务活动；他在任职期间实现了显著的顶线增长，并将业务范围延伸到了商务客户。加入 Enzymatics 之前，Paddy 曾任多个商务要职，包括 Agilent Technologies 的业务开发总监、Beckman Coulter Molecular Diagnostics 的产品开发总监以及 Invitrogen and GE Healthcare/Amersham International 产品开发部门的多个技术职位。此外，Paddy 博士目前还任职于 Lasergen 的科学顾问委员会，并且之前曾任职于 Enzymatics 的科学顾问委员会。他拥有南安普敦大学的核酸化学博士学位和赫瑞瓦特大学荣誉商学士学位。
-
Jim Thorburn
首席财务官
查看个人简历/出版物x
Jim Thorburn
首席财务官
Thorburn 是一名经验丰富的技术高管，在私营和国营技术公司有 30 多年的财务和运营从业经验。在加入 Twist Bioscience 前，他曾担任 Televerde 首席销售官，后者是一家专注于在全球扩展业务的需求生成和销售促进的企业。在加入 Televerde 之前，他曾担任过数家私营和国营公司的临时首席财务官，包括 Enercore、Next Autoworks、Fisker Automotive 和 Numonyx（被 Micron 收购）。在担任 Numonyx 的临时首席财务官期间，他负责协调 ST Microelectronics 与 Intel Flash Memory 部门的合并，并协调融资事宜以支持这家营收 20 亿美元公司的运营。在加入 Numonyx 之前，他曾担任 ZiLOG 的董事长兼首席执行官，带领共同公司成功转型、成功上市以及成功出售给 IXYS。Jim 一直担任 Texas Pacific Group (TPG) 的运营顾问、ON Semiconductor 的首席运营官兼联席总裁，并领导了 ON 的收购和上市。
在加入 ON 之前，他曾在 National Semiconductor 的多个业务部门担任过多个财务高管职务。
Thorburn 先生曾任 IXYS Corporation 的董事会成员。他在格拉斯哥大学获得农业经济学的理学士学位（荣誉），并通过了英国皇家特许管理会计师公会考试。
-
Aaron Sato 博士
首席科学官
查看个人简历/出版物x
Aaron Sato 博士
首席科学官
Aaron 是一位经验丰富的生物学领导者，擅长团队管理，发现和开发新的一流抗体疗法。在加入 Twist Bioscience 之前，他曾担任 LakePharma 的首席科学官，领导加利福尼亚抗体中心，致力于为客户研发新的抗体疗法。在 LakePharma 之前，他曾相继担任 Sutro Biopharma, Inc. 的研究副总裁和 Surrozen 的蛋白质科学副总裁，监管所有研发职能部门。他还曾在 OncoMed Pharmaceuticals 担任抗体工程高级总监，负责人类抗体先导化合物的发现，并通过 IND 申请，担任过数个关键抗体项目的项目组组长。在加入 OncoMed 之前，Aaron 在 Dyax Corp.履任要职，最终担任先导化合物发现高级总监，采用公司专有的噬菌体展示技术领导抗体、肽和小型蛋白质的发现。他在麻省理工学院获得博士学位，学习了 MHC II 类结构功能关系。在抗体领域，他发表了 30 多篇同行评审论文，并申请了 40 项授权专利。
出版物
A synthetic bispecific antibody capable of neutralizing SARS-CoV-2 Delta and Omicron.
Tom Z. Yuan, Carolina Lucas, Valter S. Monteiro, Akiko Iwasaki, Marisa L. Yang, Hector F. Nepita, Ana G. Lujan Hernandez, Joseph M. Taft, Lester Frei, Sai T. Reddy, Cédric R. Weber, Kevin P. Malobisky, Rodrigo Mesquita, Aaron K. Sato. bioRxiv. 2022.01.04.474803; doi: https://doi.org/10.1101/2022.01.04.474803
Yuan TZ, Garg P, Wang L, Willis JR, Kwan E, Hernandez AGL, Tuscano E, Sever EN, Keane E, Soto C, Mucker EM, Fouch ME, Davidson E, Doranz BJ, Kailasan S, Aman MJ, Li H, Hooper JW, Saphire EO, Crowe JE, Liu Q, Axelrod F, Sato AK. MAbs. 2022 Jan-Dec;14(1):2002236. doi: 10.1080/19420862.2021.2002236. PMID: 34967699; PMCID: PMC8726723.
Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study.
Hastie KM, Li H, Bedinger D, Schendel SL, Dennison SM, Li K, Rayaprolu V, Yu X, Mann C, Zandonatti M, Diaz Avalos R, Zyla D, Buck T, Hui S, Shaffer K, Hariharan C, Yin J, Olmedillas E, Enriquez A, Parekh D, Abraha M, Feeney E, Horn GQ; CoVIC-DB team1, Aldon Y, Ali H, Aracic S, Cobb RR, Federman RS, Fernandez JM, Glanville J, Green R, Grigoryan G, Lujan Hernandez AG, Ho DD, Huang KA, Ingraham J, Jiang W, Kellam P, Kim C, Kim M, Kim HM, Kong C, Krebs SJ, Lan F, Lang G, Lee S, Leung CL, Liu J, Lu Y, MacCamy A, McGuire AT, Palser AL, Rabbitts TH, Rikhtegaran Tehrani Z, Sajadi MM, Sanders RW, Sato AK, Schweizer L, Seo J, Shen B, Snitselaar JJ, Stamatatos L, Tan Y, Tomic MT, van Gils MJ, Youssef S, Yu J, Yuan TZ, Zhang Q, Peters B, Tomaras GD, Germann T, Saphire EO. Science. 2021 9 月 23 日:eabh2315. doi: 10.1126/science.abh2315. Online ahead of print. PMID: 34554826
Liu Q, Garg P, Hasdemir B, Wang L, Tuscano E, Sever E, Keane E, Hernandez AGL, Yuan TZ, Kwan E, Lai J, Szot G, Paruthiyil S, Axelrod F, K Sato A. MAbs. 2021 Jan-Dec;13(1):1893425. doi: 10.1080/19420862.2021.1893425. PMID: 33706686; PMCID: PMC7971233.
Tom Z Yuan, Ana G Lujan Hernandez, Erica Keane, Qiang Liu, Fumiko Axelrod, Shweta Kailasan, Madeleine Noonan-Shueh, M Javad Aman, Aaron K Sato, Yasmina N Abdiche. Antib Ther. 2020 8 月 1 日 : tbaa016. Published online 2020 8 月 1 日. doi: 10.1093/abt/tbaa016. PMCID: PMC7454256.
Huang N, Shimomura E, Yin G, Tran C, Sato A, Steiner A, Heibeck T, Tam M, Fairman J, Gibson FC 3rd. J Clin Periodontol. 2019 Feb;46(2):197-205. doi: 10.1111/jcpe.13047. Epub 2019 Jan PubMed PMID:30578564.
5月 26;10(6). pii: E286. doi: 10.3390/v10060286. PubMed PMID: 29861435.
Kapoor N, Vanjak I, Rozzelle J, Berges A, Chan W, Yin G, Tran C, Sato AK, Steiner AR, Pham TP, Birkett AJ, Long CA, Fairman J, Miura K. Malaria Biochemistry. 2018 2 月 6 日;57(5):516-519. doi: 10.1021/acs.biochem.7b01099. Epub 2018 1 月 16 日. PubMed PMID: 29323879; PubMed Central PMCID: PMC5803671.
Yin G, Stephenson HT, Yang J, Li X, Armstrong SM, Heibeck TH, Tran C, Masikat MR, Zhou S, Stafford RL, Yam AY, Lee J, Steiner AR, Gill A, Penta K, Pollitt S, Baliga R, Murray CJ, Thanos CD, McEvoy LM, Sato AK, Hallam TJ. Sci Rep. 2017 6 月 8 日;7(1):3026. doi:10.1038/s41598-017-03192-z. PubMed PMID: 28596531; PubMed Central PMCID: PMC5465077.
Xu Y, Jiang G, Tran C, Li X, Heibeck TH, Masikat MR, Cai Q, Steiner AR, Sato AK, Hallam TJ, Yin G. Org. Process Res. Dev., 2016, 20 (6): 1034–1043.
Currier NV, Ackerman SE, Kintzing JR, Chen R, Filsinger Interrante M, Steiner A, Sato AK, Cochran JR. Mol Cancer Ther. 2016 Jun;15(6):1291-300. doi: 10.1158/1535-7163.MCT-15-0881. Epub 2016 3 月 29 日. PubMed PMID: 27197305.
Yen WC, Fischer MM, Axelrod F, Bond C, Cain J, Cancilla B, Henner WR, Meisner R, Sato A, Shah J, Tang T, Wallace B, Wang M, Zhang C, Kapoun AM, Lewicki J, Gurney A, Hoey T. Clin Cancer Res. 2015 5月 1;21(9):2084-95. doi: 10.1158/1078-0432.CCR-14-2808. PubMed PMID: 25934888.
Cai Q, Hanson JA, Steiner AR, Tran C, Masikat MR, Chen R, Zawada JF, Sato AK, Hallam TJ, Yin G. Biotechnol Prog. 2015 May-Jun;31(3):823-31. doi: 10.1002/btpr.2082. Epub 2015 4 月 18 日.PubMed PMID: 25826247.
Methods to Make Homogenous Antibody Drug Conjugates.
Kline T, Steiner AR, Penta K, Sato AK, Hallam TJ, Yin G. Pharm Res. 2015 Nov;32(11):3480-93. doi:10.1007/s11095-014-1596-8. Epub 2014 12 月 16 日. PubMed PMID: 25511917; PubMed Central PMCID: PMC4596908.
Production of bispecific antibodies in "knobs-into-holes" using a cell-free expression system.
Xu Y, Lee J, Tran C, Heibeck TH, Wang WD, Yang J, Stafford RL, Steiner AR, Sato AK, Hallam TJ, Yin G. MAbs. 2015;7(1):231-42. doi: 10.4161/19420862.2015.989013. PubMed PMID: 25427258; PubMed Central PMCID: PMC4623329.
A general sequence processing and analysis program for protein engineering.
Stafford RL, Zimmerman ES, Hallam TJ, Sato AK. J Chem Inf Model. 2014 10 月 27 日;54(10):3020-32. doi: 10.1021/ci500362s. Epub 2014 10 月 3 日. PubMed PMID: 25243907.
In vitro Fab display: a cell-free system for IgG discovery.
Stafford RL, Matsumoto ML, Yin G, Cai Q, Fung JJ, Stephenson H, Gill A, You M, Lin SH, Wang WD, Masikat MR, Li X, Penta K, Steiner AR, Baliga R, Murray CJ, Thanos CD, Hallam TJ, Sato AK. Protein Eng Des Sel. 2014 Apr;27(4):97-109. doi: 10.1093/protein/gzu002. Epub 2014 2 月 28 日. PubMed PMID: 24586053; PubMed Central PMCID: PMC3966677.
Groff D, Armstrong S, Rivers PJ, Zhang J, Yang J, Green E, Rozzelle J, Liang S, Kittle JD Jr, Steiner AR, Baliga R, Thanos CD, Hallam TJ, Sato AK, Yam AY. MAbs. 2014 May-Jun;6(3):671-8. doi: 10.4161/mabs.28172. Epub 2014 2 月 11 日. PubMed PMID: 24517929; PubMed Central PMCID: PMC4011911.
Zimmerman ES, Heibeck TH, Gill A, Li X, Murray CJ, Madlansacay MR, Tran C, Uter NT, Yin G, Rivers PJ, Yam AY, Wang WD, Steiner AR, Bajad SU, Penta K, Yang W, Hallam TJ, Thanos CD, Sato AK. Bioconjug Chem. 2014 2 月 19 日;25(2):351-61. doi: 10.1021/bc400490z. Epub 2014 1 月 29 日. PubMed PMID: 24437342.
Gurney A, Axelrod F, Bond CJ, Cain J, Chartier C, Donigan L, Fischer M, Chaudhari A, Ji M, Kapoun AM, Lam A, Lazetic S, Ma S, Mitra S, Park IK, Pickell K, Sato A, Satyal S, Stroud M, Tran H, Yen WC, Lewicki J, Hoey T. Proc Natl Acad Sci U S A. 2012 7 月 17 日;109(29):11717-22. doi: 10.1073/pnas.1120068109. Epub 2012 7 月 2 日. PubMed PMID: 22753465; PubMed Central PMCID: PMC3406803.
DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency.
Hoey T, Yen WC, Axelrod F, Basi J, Donigian L, Dylla S, Fitch-Bruhns M, Lazetic S, Park IK, Sato A, Satyal S, Wang X, Clarke MF, Lewicki J, Gurney A. Cell Stem Cell. 2009 8 月 7 日;5(2):168-77. doi: 10.1016/j.stem.2009.05.019. PubMed PMID: 19664991.
van der Horst EH, Chinn L, Wang M, Velilla T, Tran H, Madrona Y, Lam A, Ji M, Hoey TC, Sato AK. Neoplasia. 2009 Apr;11(4):355-64. PubMed PMID: 19308290; PubMed Central PMCID: PMC2657888.
Development of an Antibody Screening Assay for Selection of Production Cell Lines. Idusogie E. E., Castro J.M., Casipit C., Sato A.,Terasawa Y., and Mulkerrin M.G. Bioprocess Int. 2008 April: 20-33.
Hills R, Mazzarella R, Fok K, Liu M, Nemirovskiy O, Leone J, Zack MD, Arner EC, Viswanathan M, Abujoub A, Muruganandam A, Sexton DJ, Bassill GJ, Sato AK, Malfait AM, Tortorella MD. J Biol Chem. 2007 4 月 13 日;282(15):11101-9. Epub 2007 2 月 20 日. PubMed PMID: 17311924.
Sato AK, Viswanathan M, Kent RB, Wood CR. 2006 Dec;17(6):638-42. Epub 2006 10 月 17 日. Review. PubMed PMID: 17049837.
Discovery of human antibodies against the C5aR target using phage display technology.
Huang L, Sato AK, Sachdeva M, Fleming T, Townsend S, Dransfield DT. J Mol Recognit. 2005 Jul-Aug;18(4):327-33. PubMed PMID: 15706605.
Phage display-derived peptides as therapeutic alternatives to antibodies.
Ladner RC, Sato AK, Gorzelany J, de Souza M. Drug Discov Today. 2004 6 月 15 日;9(12):525-9. Review. PubMed PMID: 15183160.
Sato A.K. Use of peptide phage display in therapeutics, diagnostics, and affinity separations. Biopolymers. 2003 71(3) 316.
Development of mammalian serum albumin affinity purification media by peptide phage display.
Sato AK, Sexton DJ, Morganelli LA, Cohen EH, Wu QL, Conley GP, Streltsova Z, Lee SW, Devlin M, DeOliveira DB, Enright J, Kent RB, Wescott CR, Ransohoff TC, Ley AC, Ladner RC. Biotechnol Prog. 2002 Mar-Apr;18(2):182-92. PubMed PMID: 11934284.
Nitriles form mixed-coligand complexes with (99m)Tc-HYNIC-peptide.
Liu G, Wescott C, Sato A, Wang Y, Liu N, Zhang YM, Rusckowski M, Hnatowich DJ. Nucl Med Biol. 2002 Jan;29(1):107-13. PubMed PMID: 11786281.
Sato AK, Zarutskie JA, Rushe MM, Lomakin A, Natarajan SK, Sadegh-Nasseri S, Benedek GB, Stern LJ. J Biol Chem. 2000 1 月 21 日;275(3):2165-73. PubMed PMID: 10636922.
Sato AK, Sturniolo T, Sinigaglia F, Stern LJ. 1999 Dec;60(12):1227-36. PubMed PMID: 10626736.
Extracellular antigen processing and presentation by immature dendritic cells.
Santambrogio L, Sato AK, Carven GJ, Belyanskaya SL, Strominger JL, Stern LJ. Proc Natl Acad Sci U S A. 1999 12 月 21 日;96(26):15056-61. PubMed PMID: 10611337; PubMed Central PMCID: PMC24772.
Abundant empty class II MHC molecules on the surface of immature dendritic cells.
Santambrogio L, Sato AK, Fischer FR, Dorf ME, Stern LJ. Proc Natl Acad Sci U S A. 1999 12 月 21 日;96(26):15050-5. PubMed PMID: 10611336; PubMed Central PMCID: PMC24771.
Zarutskie JA, Sato AK, Rushe MM, Chan IC, Lomakin A, Benedek GB, Stern LJ. Biochemistry. 1999 5月 4;38(18):5878-87. PubMed PMID: 10231540.
Frayser M, Sato AK, Xu L, Stern LJ. Protein Expr Purif. 1999 Feb;15(1):105-14. PubMed PMID: 10024477.
Sato, A.K., Bitten E.R., Lambert D., and Rousslang K.W. SPIE Proceedings 1994 2137 343-351.
Sato AK, Bitten ER, Senear DF, Alexander Ross JB, Rousslang KW.J Fluoresc. 1994 Jun;4(2):195-201. doi: 10.1007/BF01881888. PubMed PMID: 24233382.
-
陈思远
首席技术官
查看个人简历/出版物x
陈思远
首席技术官
陈博士是一位战略思想家，他在识别、开发和发布 NGS、合成生物学和其他生命科学领域的创新产品方面有着丰富经验。Twist 成立后不久，他就加入了公司，主要负责合成生物学和 NGS 产品系列的开发。陈博士构思并实施了包含对 SARS-CoV-2 和其他传染病的合成控制在内的全新 NGS 产品线，开发了基因合成和 NGS 靶向富集生物化学、工作流、试剂盒和基础设施，并联合硬件、软件和硅等领域的工程师们共同构建了公司的原型 DNA 合成器，为 Twist 奠定了技术基础，实现了规模化生产。陈博士发表了众多经过同行评议的论文，并在寡核苷酸合成和合成寡核苷酸的应用领域拥有多项专利。他在威斯康星大学麦迪逊分校获得了化学博士学位，在中国北京大学获得了化学学士学位。
-
Paula Green
人力资源高级副总裁
查看个人简历/出版物x
Paula Green
人力资源高级副总裁
Paula Green 是一位经验丰富的人力资源执行官，他在开发和使用有关提升领导力、赋能高效组织的高影响力人员战略、解决方案、流程和工具方面有着骄人业绩。加入 Twist Bioscience 之前，她曾担任 QIAGEN 公司的人力资源副总裁，并在并购重组和其他重大的企业交易中负责带领 50 名人力资源专家，为 4,000 名员工提供支持。她曾是 Operon Technologies（被 QIAGEN 收购）的人力资源经理，主要负责制定战略、监督所有员工的福利以及提供培训、招聘和留用项目。她还曾担任旧金山联邦住房贷款银行的人力资源顾问。Paula 拥有旧金山大学的组织行为学学士学位。
-
Bill Banyai 博士
先进技术开发高级副总裁兼数据存储总经理
查看个人简历/出版物x
Bill Banyai 博士
先进技术开发高级副总裁兼数据存储总经理
Bill 是一位经验丰富的企业家和硅工程专家。他曾是四家初创企业的创始人或首位员工，并为初创企业提供咨询。作为 Complete Genomics 的硬件工程副总裁，他主导建立了自己的测序技术，并交付了三代人类基因组芯片和测序仪。Bill 曾两次获得美国国防部高级研究计划局 (DARPA) 的数百万美元拨款，用于开发基于硅微机械加工的创新技术。Bill 的职业生涯横跨了研究、产品开发和半导体器件加工等领域。他拥有亚利桑那大学的光学科学博士学位和密歇根大学的电子科学硕士学位，并曾在劳伦斯利弗莫尔国家实验室担任物理学家。
出版物
Human Genome Sequencing Using Unchained Base Reads on Self-Assembling DNA Nanoarrays.Drmanac R, Sparks AB, Callow MJ, Halpern AL, Burns NL, Kermani BG, Carnevali P, Nazarenko I, Nilsen GB, Yeung G, Dahl F, Fernandez A, Staker B, Pant KP, Baccash J, Borcherding AP, Brownley A, Cedeno R, Chen L, Chernikoff D, Cheung A, Chirita R, Curson B, Ebert JC, Hacker CR, Hartlage R, Hauser B, Huang S, Jiang Y, Karpinchyk V, Koenig M, Kong C, Landers T, Le C, Liu J, McBride CE, Morenzoni M, Morey RE, Mutch K, Perazich H, Perry K, Peters BA, Peterson J, Pethiyagoda CL, Pothuraju K, Richter C, Rosenbaum AM, Roy S, Shafto J, Sharanhovich U, Shannon KW, Sheppy CG, Sun M, Thakuria JV, Tran A, Vu D, Zaranek AW, Wu X, Drmanac S, Oliphant AR, Banyai WC, Martin B, Ballinger DG, Church GM, Reid CA.
Science. 2010 327(5961) 78-81Modular MEMS design and fabrication for an 80 x 80 transparent optical cross-connect switch.Fernandez A, Staker BP, Owens WE, Muray LP, Spallas JP, Banyai WC.
Proceedings SPIE - Optomechatronic Micro/Nano Components, Devices, and Systems. 2004 5604 208-217Scaling behavior in interference lithography.Agayan RR, Banyai WC, Fernandez AJ.
Proceedings SPIE - Emerging Lithographic Technologies II. 1998 3331 662-672Time-to-frequency converter for measuring picosecond optical pulses.Kauffman MT, Banyai WC, Godil AA, Bloom DM.
Applied Physics Letters. 1994 64(3) 270-272Applications of time lens optical systems.Kauffman MT, Godil AA, Auld BA, Banyai WC, Bloom DM.
Electronics Letters. 1993 29(3) 268-269Interaction of super-intense light fields with atoms and surfaces.Downer MC, Banyai WC, Wood WM, Anacker DC, Erskine JL.
Proceedings SPIE - Picosecond and Femtosecond Spectroscopy from Laboratory to Real World. 1990 1209 166-174Spectral shifting of femtosecond pulses in atmospheric density plasmas.Spectral shifting of femtosecond pulses in atmospheric density plasmas.
Picosecond pump-probe interferometric measurement of optical nonlinearities in channel waveguides.Finlayson N, Banyai WC, Seaton CT, Stegeman GI, O'Neill M, Cullen TJ, Ironside CN.
Optics Letters. 1989 14(10) 532-534Optical nonlinearities in CdSxSe1-x-doped glass waveguides.Finlayson N, Banyai WC, Seaton CT, Stegeman GI, O'Neill M, Cullen TJ, Ironside CN.
Journal of the Optical Society of America B: Optical Physics. 1989 6(4) 675-684Saturation of the nonlinear refractive-index change in a semiconductor-doped glass channel waveguide.Banyai WC, Finlayson N, Seaton CT, Stegeman GI, O’Neill M, Cullen TJ, Ironside CN.
Applied Physics Letters. 1989 54(6) 481-483Observation of ultrafast nonlinear polarization switching induced by polarization instability in a birefringent fiber rocking filter.Trillo S, Wabnitz S, Banyai WC, Finlayson N, Seaton CT, Stegeman GI, Stolen RH.
IEEE Journal of Quantum Electronics. 1989 25(1) 104-112Picosecond switching induced by saturable absorption in a nonlinear directional coupler.Finlayson N, Banyai WC, Wright EM, Seaton CT., Stegeman GI, Cullen TJ, Ironside CN.
Applied Physics Letters. 1988 53(13) 1144-1146Picosecond nonlinear polarization switching with a fiber filter.Trillo S, Wabnitz S, Finlayson N, Banyai WC, Seaton CT, Stegeman GI, Stolen RH.
Applied Physics Letters. 1988 53(10) 837-839Nonlinear-optical effects in ion-exchanged semiconductor-doped glass waveguides.Ironside CN, Cullen TJ, Bhumbra BS, Bell JA, Banyai WC, Finlayson N, Seaton CT, Stegeman GI.
Journal of the Optical Society of America B: Optical Physics. 1988 5(2) 492-495High-speed intensity-dependent refractive index in semiconductor-doped glasses.Seaton CT, Stegeman GI, Yao SS, Karaguleff C, Fortenberry R, Gabel A, Banyai W, Assanto G.
Proceedings SPIE - Advances in Materials for Active Optics. 1985 567 132 -
Tracey Mullen, MBA
Senior Vice President of Biopharma
查看个人简历/出版物x
Tracey Mullen, MBA
Senior Vice President of Biopharma
Tracey joined Twist in December 2021 through the acquisition of Abveris, a company offering premium in vivo antibody drug discovery services, in November 2021. Prior to Twist, she served as CEO of Abveris. Tracey initially served as Abveris’ chief operating officer where she managed operations and project development for both therapeutic and critical reagent in vivo antibody discovery campaigns. Before Abveris, she served on the antibody discovery team at Biogen where she helped implement the technology transfer of the Adimab yeast display platform for antibody discovery and engineering. Throughout her tenure at Biogen, Tracey worked to optimize the in vitro discovery of antibodies to traditionally difficult therapeutic targets, including leveraging the Adimab platform to generate antibodies against GPCRs. Previously she worked for a contract research organization specializing in in vivo antibody. She received her B.S. in Chemical and Biological Engineering from the Massachusetts Institute of Technology and her Executive MBA from Quantic School of Business and Technology.
-
Nimisha Srivastava, Ph.D.
Senior Vice President of R&D
查看个人简历/出版物x
Nimisha Srivastava, Ph.D.
Senior Vice President of R&D
Nimisha joined Twist in March 2014 and was instrumental in automating processes and procedures to fuel the growth of Twist into a leading global manufacturer of synthetic DNA. She built out the core technology team and scaled up key laboratory processes, workflows and automation, which enabled the high-throughput production of novel synthetic DNA-based offerings. Prior to joining Twist, Nimisha held key technical and leadership positions at various startups as well as academic and national laboratories where she drove the development and scale up of microfluidics technologies for multiplexed pathogen detection and in vitro diagnostics. She holds a B.S. in chemical engineering from the Indian Institute of Technology, New Delhi and an M.S. and Ph.D. in chemical engineering from the University of Michigan, Ann Arbor where she studied the intersection of genetics, miniaturization, and dynamics of complex fluids.
出版物
Srivastava N., Brennan J.S., Renzi R.F., Wu M., Branda S.S, Singh A.K, and Herr A.E, (2009), ‘Fully Integrated Microfluidic Platform Enabling Automated Phosphoprofiling of Macrophage Response’, Analytical Chemistry
Srivastava N., Changsong D., Judson A., McDonald N., and Meinhart C.D. (2010), ‘A unified scaling model for flow through a lattice of microfabricated posts’, Lab on a Chip, DOI:10.1039/B919942J
Srivastava N., Burns M.A. ‘Electronic Drop Sensing In Microfluidic Devices: Automated Operation of a Nanoliter Viscometer’ Lab On A Chip 6: 744 -751(2006)
Srivastava N., Burns M.A. ‘Analysis of non-Newtonian Liquids using a microfluidic capillary viscometer’ Analytical Chemistry 78: 6890-6896 (2006)
Srivastava N., Davenport R.D., Burns M.A. ‘A Nanoliter Viscometer for analyzing blood plasma and other liquid samples’ Analytical Chemistry 77(2): 383-392, 2005
Pal R., Yang M., Lin R., Johnson B.N., Srivastava N., Razzacki Z., et al ‘An integrated microfluidic device for
influenza and other genetic analyses’. Lab on A Chip, Cover Page, 5(10), 1024, 2005Srivastava N., Roy A., Pant N., Bhaskarwar A.N. ‘Washing Kinetics of a novel pollution preventing ink’ Chemical Engineering Science 60: 1725-1731, 2005
Research Highlight ‘Nanolitre Viscometer’ in Lab Chip 5: 370-373, 2005
-
Erin Smith
政府事务和公共政策高级副总裁
查看个人简历/出版物x
Erin Smith
政府事务和公共政策高级副总裁
Erin 于 2020 年 6 月加入了 Twist，她积极同主要利益相关者和政府官员合作，在推动行业议程方面展现出了出色的领导力。此前，Erin 曾在 Gilead Sciences 主导政府事务项目的扩展。再之前，Erin 领导创建了包括 DaVita Rx 在内的其他公司的政府事务项目。Erin 的公务员生涯始于最近上任的能源部长和前州长 Rick Perry 的办公室。她在那里担任医疗保健政策和财务顾问，专注于州和联邦资源与政策的协调。Erin 在休斯顿大学法律中心任兼职教师，教授立法策略、政府事务和公共政策等课程。她在休斯敦大学法律中心获得了荣誉法学博士学位，在德克萨斯大学健康科学中心获得了荣誉硕士学位，在德鲁大学获得了荣誉学士学位。
-
Angela Bitting
首席 ESG 官兼公司事务高级副总裁
查看个人简历/出版物x
Angela Bitting
首席 ESG 官兼公司事务高级副总裁
作为一名在生物制药行业拥有超过 25 年经验的高级传播主管，Angela 擅于清晰的表达和一致的传播，这让她在主要利益相关者中获得了一定的知名度，并承担了整个公司的文化和传播方面的工作。在加入 Twist 之前，她有 20 年的咨询服务经验，与生物制药、医疗设备和诊断领域的客户合作创建了关键信息，从而实现与外部受众的有效沟通。在开始咨询服务之前，Angela 曾担任 Exelixis 公司的投资者关系和企业传播部主管。她也在 Russell-Welsh 公司（一家精品医疗通信公司）工作了数年，期间与各种公共和私人客户就广泛的通信服务进行过合作。她拥有华盛顿大学的细胞和分子生物学理学学士学位和商业营销文学学士学位。她目前担任国家慈善联盟当地分会的临时副总裁。
-
Dennis Cho
General Counsel and Chief Ethics and Compliance Officer
查看个人简历/出版物x
Dennis Cho
General Counsel and Chief Ethics and Compliance Officer
Dennis Cho is a seasoned in-house business attorney with a proven track record of agile strategic guidance and practical problem solving. Prior to Twist, he served as assistant general counsel at CytomX Therapeutics, where he was department head for all deals and contracts as well as day-to-day lead on compliance and numerous other legal subject matters. Prior to CytomX, Mr. Cho was the lead transactional attorney on antibody-related licenses and collaborations, major commercial agreements, and combination trials at Seattle Genetics. Before that, he spent nine years at Celgene as the lead West Coast attorney supervising over 100 business transactions, including in- and out- licenses, options, collaborations and M&A agreements, and held primary legal responsibility for Celgene’s alliances, equity investments and “big data” machine learning initiative. Prior to Celgene, Mr. Cho served as general counsel for four private and public companies. He earned his J.D. and a B.A. in Molecular Cell Biology (Genetics) from University of California, Berkeley.
-
Steffen Hellmold
Senior Vice President, Business Development for Data Storage
查看个人简历/出版物x
Steffen Hellmold
Senior Vice President, Business Development for Data Storage
Mr. Hellmold joined Twist in October 2021, bringing more than 25 years of industry experience in product, technology as well as business development roles in semiconductor memory and data storage. He will be responsible for promoting, educating and driving market awareness and reception for DNA data storage. His expertise includes driving product roadmap leadership and establishing strategic relationships with ecosystem stakeholders to fuel the adoption of DNA data storage solutions across existing and emerging archive storage use cases. Before joining Twist, Mr. Hellmold was Vice President, Corporate Strategy and Business Development for Strategic Initiatives at Western Digital. Prior to Western Digital, Mr. Hellmold held executive management positions at Everspin, SandForce, Seagate Technology, Lexar Media, Samsung Semiconductor, Fujitsu and SMART Modular. Mr. Hellmold has been deeply engaged in various industry trade associations and standards organizations including co-founding the DNA Data Storage Alliance as well as USB Flash Drive Alliance. He holds an Economic Electrical Engineering degree (EEE) from the Technical University of Darmstadt, Germany.
团队介绍
