The NGS Human Core Exome provides the ability to lower sequencing costs, increase sample throughput, and achieve a higher depth of coverage across target regions with uncompromising quality.
33 Mb CCDS coverage
99% of ClinVar variants covered
99.3% of targeted regions covered at 20x with 5.3 Gb
The NGS Human Core Exome provides the ability to lower sequencing costs, increase sample throughput, and achieve a higher depth of coverage across target regions with uncompromising quality.
33 Mb CCDS coverage
99% of ClinVar variants covered
99.3% of targeted regions covered at 20x with 5.3 Gb
Twist Human Core Exome Kit resulted in a higher number of targets covered with 20 or 30 reads compared to leading competitors.
Twist Bioscience provides higher library complexity than the competitor kits resulting in a lower duplication rate
The improved coverage uniformity of the Twist Human Core Exome reduces the amount of sequencing required to achieve the desired coverage depth.
Twist Human Core Exome Kit resulted in a higher number of targets covered with 20 or 30 reads compared to leading competitors.
Twist Bioscience provides higher library complexity than the competitor kits resulting in a lower duplication rate
The improved coverage uniformity of the Twist Human Core Exome reduces the amount of sequencing required to achieve the desired coverage depth.
The ability to simply add your spike-in panel to the Core Exome creates added differentiation based on your research requirements. Rapid design optimization with a quick production turnaround reduces overall development time for your custom exome.
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Additional content with high enrichment uniformity
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Increased coverage of specific genes covered by Core Exome
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Optimization of spike-in ratio by customer
The ability to simply add your spike-in panel to the Core Exome creates added differentiation based on your research requirements. Rapid design optimization with a quick production turnaround reduces overall development time for your custom exome.
-
Additional content with high enrichment uniformity
-
Increased coverage of specific genes covered by Core Exome
-
Optimization of spike-in ratio by customer
The Twist Human Core Exome are for research use only, and subject to additional use restrictions as set forth in Twist’s Supply Terms and Conditions.
The Twist Human Core Exome are for research use only, and subject to additional use restrictions as set forth in Twist’s Supply Terms and Conditions.
White Paper
The Importance of Coverage Uniformity Over On-Target Rate for Efficient Targeted NGS
Application Note
Evaluating the Efficiency of the Twist Human Core Exome Kit for Target Sequencing
White Paper
The Importance of Coverage Uniformity Over On-Target Rate for Efficient Targeted NGS
Application Note
Evaluating the Efficiency of the Twist Human Core Exome Kit for Target Sequencing
Exome Sequencing Savings Calculator
Human Core Exome Panel
Number Of Samples
Mean Target Coverage
The number of times a given nucleotide in the genome has been read on average
Sequencing Platform
Cost Per Run
Compared To
| Twist | Agilent V6 | |
|---|---|---|
| GB Per Exome* |
Gb / exome
Fold-80
On Target Rate
Duplicate Rate
Target space
4.0
1.32
98 %
1.6 %
|
Gb / exome
Fold-80
On Target Rate
Duplicate Rate
Target space
4.0
1.32
98 %
1.6 %
|
| Max Samples Per Run | ||
| SEQ Cost Per Sample | $ | $ |
| SEQ Cost Per Project | $ | $ |
Gigabases per exome are based on independent Research by CeGat and Johns Hopkins.
Max samples per run is calculated based on instrument specifications provided by Illumina using 2x150bp reads.
Sequencing cost per sample is based on Illumina sequencing kit prices and Illumina instrument specifications using 2x150bp reads.
Savings for sequencing project costs are generated from publicly listed third-party pricing and performance specifications for the referenced sequencing platform.
